We are currently in receipt of the seed corn funding grant to investigate the role of the MK2 cascade as a protective target in Alzheimer’s disease.
BBSRC/FAPESP Funding Scheme
The grant was awarded in collaboration with Dr Luis da Silva from University of São Paulo, Brazil. This work is investigating the molecular mechanisms by which activity-dependent gene transcription and protein synthesis regulates the endocytic machinery during synaptic plasticity in the hippocampus.
Control of AMPA receptor trafficking during hippocampal long-term depression (LTD): the role of the p38 MAPK-MK2 signalling cascade.
Wall MJ, Correa SAL. The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis. Seminars in Cell and Development Biology. DOI:10.1016/j.semcdb.2017.09.05
Lake D, Corrêa SAL, Müller J (2016) Negative feedback regulation of the ERK1/2 MAPK pathway. Cell Mol. Life Sic. DOI:10.1007/s00018-016-2297-8.
Arc controls AMPAR endocytosis through a direct interaction with clathrin-adaptor protein 2. eNeuro doi:10.1523/ENEURO.0144-15.2016
Sanderson TM, Hogg EL, Collingridge GLC, Corrêa SAL (2016) Hippocampal mGluR-LTD in health and disease: focus on the p38 MAPK and ERK1/2 pathways. J. Neurochem.
Eales KL, Palygin O, O’Loughlin T, Rasooli-Nejad S, Gaestel M, Müller J, Collins DR, Pankratov Y, Corrêa SAL (2014) The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat. Commun., 5:4701 doi:1038/ncomms5701.
Mabb AM, Je HS, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SAL, Ehlers MD (2014) Triad3A Regulates Synaptic Strength by Ubiquitination of Arc. Neuron, 82(6):1299-1316.
Corrêa SAL, Hunter CJ, Palygin O, Wauters S, Martin KJ, Mackenzie C, McKelvey K, Morris RGM, Pankratov Y, Arthur JSC, Frenguelli BG (2012) MSK1 regulates homeostatic and experience-dependent synaptic plasticity. J. Neurosci., 32(38):13039-13051.
Corrêa SAL, Eales, K (2012) The role of p38 MAPK and Its Substrates in Neuronal plasticity and Neurodegenerative disease. J. Signal Transduct., DOI:10.1155/2012/649079
Canal F, Palygin O, Pankratov Y, Corrêa SAL, Müller J. (2011) Compartmentalization of the MAPK scaffold protein KSR1 modulates synaptic plasticity in hippocampal neurons. FASEB J., 25(7):2362-72.